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The existence of an alternative GLP-1R has been inferred for a long time but attempts to identify it have failed and there is no obvious candidate in the genome (see It is possible that the concept of receptor promiscuity can be extended to other cases where a hormone exerts an effect without an obvious candidate receptor

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Higher doses are often used for patients requiring greater metabolic support

Paradoxically, mice lacking gamma-glutamyl transpeptidase (GGT)an enzyme essential for GSH degradationdeveloped milder fibrosis following BLM exposure [126]

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